Materiał z kanału YT Breaking Convention (https://www.youtube.com/c/BreakingConvention/videos)

Salvinorin A, the prime psychoactive compound in the Salvia divinorum plant, is the most potent naturally-occurring hallucinogen we know of. It has...

Materiał z kanału YT MAPS

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Peter Addy, PhD: Therapeutic Potential of the Plant Salvia Divinorum

Psychedelic Science 2017
https://2017.psychedelicscience.org
A six-day global gathering of the...

Danshen, the root of Salvia miltiorrhiza, is widely recognized as an effective medicine for treating cardiovascular and cerebrovascular diseases, but there are many limitations in the extraction of its active components. To overcome these limitations, our project employs synthetic biology techniques to design two synthetic pathways. Utilizing endogenously produced 4-coumaroyl-CoA in tobacco as the acyl donor, we introduce key enzymes and precursor substances exogenously to synthesize rosmarinic acid. In pathway one, we introduce danshensu, SmRAS10, and SmCYP98A14; in pathway two, we introduce 4-hydroxyphenyllactate, SmRAS10, SmCYP98A14, and SmCYP98A75. LC-MS/MS results indicate that both pathways are capable of synthesizing rosmarinic acid in tobacco leaves. Moving forward, the project will focus on further optimizing production efficiency. This not only provides a new strategy for the sustainable development of Salvia miltiorrhiza but also suggests that this method can be applied to the production of other medicinal components.

SACRED WEEDS S1 • ODC. 2
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Salvia Divinorum, also known as the diviner's sage, is potentially one of world's most hallucinogenic substances. Three specialists gather to scientifically document, for the first time, the physiological and psyc...

Materiał z kanału YT Filomena (https://www.youtube.com/channel/UCYQWTGt6uB8kvMZhE9iIzUw)

Dziękuję wszystkim uprzejmym widzom, których wsparcie zmotywowało mnie do wznowienia kanału. Wasze zaangażowanie jest nieocenione. Dedykuję Wam to nagranie...

The incidence of myocarditis has increased after COVID-19, posing a threat to public health. Traditional Chinese medicine, Salvia miltiorrhiza (Danshen), its active compounds, such as tanshinone, and a similar structure diterpenoid carnosic acid, which is also extracted from Salvia, have proven effective in treating cardiovascular diseases, including anti-inflammatory and cardioprotective benefits. However, traditional production methods are limited by high cost and time-consuming. To address this issue, we use Saccharomyces cerevisiae, leveraging its inherent MVA pathway to construct a novel synthetic pathway for the efficient production of tanshinone and carnosic acid. This sustainable, scalable method may revolutionize cardiovascular drug production, expanding applications in drug development and combating cardiovascular and cerebrovascular diseases.

Title: Heart Bodyguard: Yeast heterologous synthesis of active ingredients of Salvia

Description: The incidence of myocarditis has increased after COVID-19, posing a threat to public health. Traditional Chinese medicine, Salvia miltiorrhiza (Danshen), its active compounds, such as tanshinone, and a similar structure diterpenoid carnosic acid, which is also extracted from Salvia, have proven effective in treating cardiovascular diseases, including anti-inflammatory and cardioprotective benefits. However, traditional production methods are limited by high cost and time-consuming. To address this issue, we use Saccharomyces cerevisiae, leveraging its inherent MVA pathway to construct a novel synthetic pathway for the efficient production of tanshinone and carnosic acid. This sustainable, scalable method may revolutionize cardiovascular drug production, expanding applications in drug development and combating cardiovascular and cerebrovascular diseases.

Wiki | Official Page

Title: Herbal Code—Construction of a biosynthetic pathway for phenolic acids in model organisms

Description: Danshen, the root of Salvia miltiorrhiza, is widely recognized as an effective medicine for treating cardiovascular and cerebrovascular diseases, but there are many limitations in the extraction of its active components. To overcome these limitations, our project employs synthetic biology techniques to design two synthetic pathways. Utilizing endogenously produced 4-coumaroyl-CoA in tobacco as the acyl donor, we introduce key enzymes and precursor substances exogenously to synthesize rosmarinic acid. In pathway one, we introduce danshensu, SmRAS10, and SmCYP98A14; in pathway two, we introduce 4-hydroxyphenyllactate, SmRAS10, SmCYP98A14, and SmCYP98A75. LC-MS/MS results indicate that both pathways are capable of synthesizing rosmarinic acid in tobacco leaves. Moving forward, the project will focus on further optimizing production efficiency. This not only provides a new strategy for the sustainable development of Salvia miltiorrhiza but also suggests that this method can be applied to the production of other medicinal components.

Wiki | Official Page

[Η διάλεξη δόθηκε στην αγγλική γλώσσα]
Η ανοιχτή διάλεξη που παραχώρησε η Σίλβια Φεντερίτσι, φεμινίστρια, ακτιβίστρια και ομότιμη καθηγήτρια στο πανεπιστήμιο Hofstra στη Νέα Υόρκη, στις 19/06/2019 στο Τμήμα Πολιτικών Επιστημών του ΑΠΘ.