Immunotherapies offer great potential for treating immune-mediated diseases, but often lead to resistance and adverse effects. To address this, iGEM TU Eindhoven is developing PROMISE, a novel trained immunity vaccine utilizing antigen-functionali...

''You can do it everywhere, and you do not have to have a special situation for treating people. You can do it when you go for a swim and someone has a cramp, or you are going somewhere and you eat something that your stomach doesn't like. You can...

Title: ATLAS - Antigen Triggered Loop Activation System

Description: CAR-T cell therapy has demonstrated success in treating blood-based cancers, but faces challenges in combating solid tumors. ATLAS is a circuit designed to enhance the e...

In the present study, we engineered probiotics to produce small molecules for treating depression and Alzheimer's disease. For depression, utilizing molecular docking and SPR, we identified inosine as a molecule capable of decoupling SERT-nNOS. We...

Title: Car-Ma

Description: Immunotherapy has been gaining popularity, and examples like CAR-T have been proven efficient in treating liquid cancer. However, in solid tumours, the tumour microenvironment (TME) acts as a physical barrier and prevents phagocytosis. Moreover, M2-like phenotype tumour-associated macrophages (TAMs) in TME would promote tumour growth. Our lab is working on delivering the CAR transgene into the tumour-associated macrophages that target hepatocellular carcinoma. First, we will be knocking out SIRP-alpha through the use of Cas9 gene editing, which enhances phagocytosis. Second, we will be using self-replicating RNA to transfect the CAR into the macrophages, enabling safe and efficient transfection of CAR without any genomic integration.

Wiki

Title: SEPiA - Side-Effects and Polypharmacy interaction Ai

Description: Polypharmacy is the simultaneous use of more than five medications. While often necessary for treating multimorbid patients, polypharmacy is associated with a declin...

Linux gaming has greatly improved over the years and especially so after the release of the Steam Deck but now it seems like some developers are treating the Steam Deck like a console and having anti cheat only work on that.

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On this episode of HEY DT:
0:00 Intro
0:20 Why don't you use vanilla Arch?
7:10 Is there a place where I can see a list of all your videos?
8:26 Were you recently interviewed and where can we watch it?
9:53 How has Syncthing been treating you? Do ...

Yes, we all know it’s the right thing to do. But Michael Kimmel makes the surprising, funny, practical case for treating men and women equally in the workplace and at home. It’s not a zero-sum game, but a win-win that will result in more opportuni...

Need for Speed: Underground was a massive success for EA Black Box, thanks in no small part to breaking series conventions and treading new ground for the Need for Speed series. This video is the first of a four-part series about what I consider t...