Title: AMPlify

Description: Our team will address antibiotic resistance by developing a novel, efficient, and scalable method to produce protein-based antibiotics. Biological synthesis in bacteria is used at scale for other protein-based ...

Title: Investigating Encapsulins as a Novel Drug Delivery Platform

Description: Using alpha factor tagged encapsulins to deliver mNeon cargo to yeast cells via clathrin mediated endocytosis.

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Title: SNP-it: Point-of-Care Fluorescent SNP Detection

Description: Our team is developing an inexpensive, generalizable genetic variant detection platform for use in point-of-care, low resource settings. A combination of loop mediated is...

Title: SNP-IT: A Single Nucleotide Polymorphism Detection Platform to Inform Antiplatelet Pharmacotherapy

Description: Antiplatelet medications are a common treatment for patients after experiencing thrombotic events, such as venous throm...

Title: Investigating the Versatility of Encapsulin Protein Nanocompartments for Drug Delivery

Description: Encapsulins (Encs) are a class of proteins that self-assemble and envelope other functional cargo proteins when co-expressed. Encs are relatively simple protein shells, yet they are stable and can carry robust cargo. We believe this represents an opportunity for novel drug delivery. In this work, we investigate the intake of assembled Encs by living eukaryotic cells and whether the Enc containers can be disassembled by protein-degradation enzymes native to the targeted organism. Brewer s yeast (S. cerevisiae) was selected as the proof-of-concept organism for this project, and mNeon green was chosen as the model Enc cargo. We are cloning bacteria that will produce Enc shells with yeast mating pheromone tags displayed on their surfaces. The tags will encourage the yeast to endocytose the disguised Encs into the cell from the environment. Success will be measured by using fluorescence imaging to confirm the presence of assembled mNeon green-bearing shells within live cells.

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Title: BioXane: Engineering Bacteria in Bioreactors to Remove 1,4-Dioxane from Water Systems

Description: 1,4-Dioxane is a Group 2B carcinogen that poses immediate risk to human health and is a byproduct of many common industrial processe...

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Title: Bioxane

Description: 1,4-Dioxane, a Group 2B carcinogen that poses a risk to human health, is a toxic byproduct of many common industrial processes. Our team is engineering and optimizing a freshwater bacteria (Pseudomonas putida S...